Alexander Fleming Discovers Penicillin

Alexander Fleming Discovers Penicillin In 1928, bacteriologist Alexander Fleming made a chance discovery from an already discarded, contaminated Petri dish. The mold that had contaminated the experiment turned out to contain a powerful antibiotic, penicillin. However, though Fleming was credited with the discovery, it was over a decade before someone else turned penicillin into the miracle drug that has helped save millions of lives. Dirty Petri Dishes On a September morning in 1928, Alexander Fleming sat at his workbench at St. Marys Hospital after having just returned from a vacation at the Dhoon (his country house) with his family. Before he had left on vacation, Fleming had piled a number of his Petri dishes to the side of the bench so that Stuart R. Craddock could use his workbench while he was away. Back from vacation, Fleming was sorting through the long unattended stacks to determine which ones could be salvaged. Many of the dishes had been contaminated. Fleming placed each of these in an ever-growing pile in a tray of Lysol. Looking for a Wonder Drug Much of Flemings work focused on the search for a wonder drug. Though the concept of bacteria had been around since Antonie van Leeuwenhoek first described it in 1683, it wasnt until the late nineteenth century that Louis Pasteur confirmed that bacteria caused diseases. However, though they had this knowledge, no one had yet been able to find a chemical that would kill harmful bacteria but also not harm the human body. In 1922, Fleming made an important discovery, lysozyme. While working with some bacteria, Flemings nose leaked, dropping some mucus onto the dish. The bacteria disappeared. Fleming had discovered a natural substance found in tears and nasal mucus that helps the body fight germs. Fleming now realized the possibility of finding a substance that could kill bacteria but not adversely affect the human body. Finding the Mold In 1928, while sorting through his pile of dishes, Flemings former lab assistant, D. Merlin Pryce stopped by to visit with Fleming. Fleming took this opportunity to gripe about the amount of extra work he had to do since Pryce had transferred from his lab. To demonstrate, Fleming rummaged through the large pile of plates he had placed in the Lysol tray and pulled out several that had remained safely above the Lysol. Had there not been so many, each would have been submerged in Lysol, killing the bacteria to make the plates safe to clean and then reuse. While picking up one particular dish to show Pryce, Fleming noticed something strange about it. While he had been away, a mold had grown on the dish. That in itself was not strange. However, this particular mold seemed to have killed the Staphylococcus aureus that had been growing in the dish. Fleming realized that this mold had potential. What Was That Mold? Fleming spent several weeks growing more mold and trying to determine the particular substance in the mold that killed the bacteria. After discussing the mold with mycologist (mold expert) C. J. La Touche who had his office below Flemings, they determined the mold to be a Penicillium mold. Fleming then called the active antibacterial agent in the mold, penicillin. But where did the mold come from? Most likely, the mold came from La Touches room downstairs. La Touche had been collecting a large sampling of molds for John Freeman, who was researching asthma, and it is likely that some floated up to Flemings lab. Fleming continued to run numerous experiments to determine the effect of the mold on other harmful bacteria. Surprisingly, the mold killed a large number of them. Fleming then ran further tests and found the mold to be non-toxic. Could this be the wonder drug? To Fleming, it was not. Though he saw its potential, Fleming was not a chemist and thus was unable to isolate the active antibacterial element, penicillin, and could not keep the element active long enough to be used in humans. In 1929, Fleming wrote a paper on his findings, which did not garner any scientific interest. 12 Years Later In 1940, the second year of World War II, two scientists at Oxford University were researching promising projects in bacteriology that could possibly be enhanced or continued with chemistry. Australian Howard Florey and German refugee Ernst Chain began working with penicillin. Using new chemical techniques, they were able to produce a brown powder that kept its antibacterial power for longer than a few days. They experimented with the powder and found it to be safe. Needing the new drug immediately for the war front, mass production started quickly. The availability of penicillin during World War II saved many lives that otherwise would have been lost due to bacterial infections in even minor wounds. Penicillin also treated diphtheria, gangrene, pneumonia, syphilis, and tuberculosis. Recognition Though Fleming discovered penicillin, it took Florey and Chain to make it a usable product. Though both Fleming and Florey were knighted in 1944 and all three of them (Fleming, Florey, and Chain) were awarded the 1945 Nobel Prize in Physiology or Medicine, Fleming is still credited for discovering penicillin.

Wellbeing And Autistic Spectrum Disorder Essays

Wellbeing And Autistic Spectrum Disorder Essays Wellbeing And Autistic Spectrum Disorder Essay Wellbeing And Autistic Spectrum Disorder Essay I work as the Health A ; Safeguarding Manager at a residential school for kids aged 5-19 with Learning Disabilities. Over 50 % of these have a diagnosing of Autistic Spectrum Disorder ( ASD ) . For the intent of this TMA I am traveling to concentrate on those of this group who have severe larning disablements and associated disputing behavior and are placed with us as a 38 hebdomad residential arrangement ; hence traveling place to household during school vacations. This amounts to 42 % ( 20 ) of the entire population I work with. ASD is defined as holding communicating jobs with address, facial looks, gestures, and organic structure linguistic communication ; jobs in societal interaction such as relationships, hapless societal accomplishments, deficiency of apprehension and empathy/insight, and inappropriate oculus contact ; and jobs with flexibleness of idea, being stiff and immune to alter, and showing obsessive and ritualistic behaviors. OASSIS describes ASD as compromises childhood, and has a ruinous consequence on mundane life.A It impairs effectual communicating with and understanding of others, societal ability and flexibleness, and sets apart those with ASD from their more normal equals ; it besides gives rise to high degrees of anxiousness ( World Wide Web. oasis.co.uk ) . How so to analyze the significance of wellbeing and show the publicity of this in a group of kids and immature people already at a disadvantage through how their diagnosing impacts on them daily. As wellness and well-being is an of import portion of my function I thought it peculiarly relevant to concentrate on this more complex group who can non pass on their demands and wants efficaciously. What is wellbeing? The Cambridge Dictionary Online defines wellbeing as the province of experiencing healthy and happy , which fits with my initial ideas on the significance of this. But, as discussed in Unit 5 of Block 2 the term is a wide one and based on a more holistic attack ( K346, Block 2, Unit 5, p.68 ) . Health plays a big portion in a individual s well-being, with wellness in itself being a wide topic. Health covers both physical and mental/psychological wellness. The BMA ( 2006 ) cited a scope of factors that can impact mental wellness, such as exercising, diet, speaking about feelings and larning new accomplishments, entree to originative activities, and the environment a individual lives in ( K346, Block 2, Unit 10, Activity 10.9, Child and Adolescent Mental Health: a Guide for Healthcare, p. 33 ) . This fits with the holistic accent of the term as it is based in the basic demands of mundane life. In my workplace we were, up until April 2011, inspected by OFSTED under the five results from Every Child Matters: Change for Children that the Department for Education and Skills ( 2003 ) stated were cardinal to wellness and well-being in childhood. These were, as listed in Unit 5 ( K346, Block 2, Unit 5, p.69 ) Bing healthy Staying safe Enjoying and accomplishing Making a positive part Achieving economic well-being Indeed, the personal attention files for our immature people were based on these results which placed wellbeing at the Centre of service bringing, and aimed to supply grounds that wellbeing was being monitored, addressed and promoted. We now know that ECM is defunct and it appears there will be more accent on safeguarding and cultural and diverseness demands from an inspectorate point of position. This is following the Munro Review into Child Protection ( hypertext transfer protocol: //www.education.gov.uk/munroreview/ ) which is presently driving the policy in monitoring and farther developing societal attention services for kids and immature people. I feel this so demonstrates that the significance of wellbeing on paper in my workplace and company is led by the current policy driver and inspectorate outlooks. Indeed, attention staffs are being asked to get down looking at accommodating attention files to show grounds that the new cardinal results during review are covered within the certification available. This so appears to be policy led instead than led by the demands of the kids and immature people we care for. Bradshaw and Mayhew ( 2005 ) compartmentalise wellbeing into four groups. Physical wellbeing which includes diet, maltreatment, disregard, mortality, morbidity and accidents ; cognitive well-being related to education attainment ; behavioral well-being related to alcohol, drugs, baccy and offense ; and emotional well-being related to mental unwellness, self-esteem and felicity ( K346, Block 2, Unit 5, p.68 ) . I would reason this concept of wellbeing encompasses best the wide significance of such a subjective term, and though policy accent may alter, new constructs can be incorporated into at least one of the four groups. Before I look at the significance and publicity of wellbeing within my chosen group based on Bradshaw and Mayhew ( 2005 ) wellbeing groups, I besides need to see how well-being is measured for this group. Subjective tools such as a Quality of Life Tool as discussed in activity 5.6 and 5.7 ( K346, Block 2, Unit 5 ) rely to a great extent on kids and immature people holding the cognitive ability to be able to reply the simple inquiries. My chosen group map at a really low degree and utilize augmentative communicating AIDSs such as Picture Exchange Systems ( PECS ) merely to let them to hold a successful twenty-four hours without intensifying anxiousnesss. For this group of people their wellbeing depends on placing schemes to understate their anxiousness, this is a precedence. I would reason that a step of wellbeing for this group is based on the recording of what they have been able to entree and accomplish daily without presentations of disputing behavior. Though I concur with Action for Children s stance that kids s positions need to be listened to in estimating their positions on their ain well-being ( K346, Block 2, Unit 5, Activity 5.4 ) , the profound communicating troubles within this group make immense barriers to enable this. By interceding closely with the parents and other professionals involved in the attention of my identified group we are able to advance their personal well-being through the voices of those closest to them. This was felt to be of import in Annette Koshti-Richman s article Listening to parents and carers of kids with disablements which emphasised the demand for professionals to keep unfastened communicating channels with parents ( K346, Block 2, Unit 9, Activity 9.13 ) . My ain experience has shown me that parent s discovery, or are still happening coming to footings with their kid holding an ASD diagnosing really hard. As described in Unit 9 ( K346, Block 2, Unit 9, p.106 ) parents speak of a sense of loss-of the possible activities, accomplishments and escapades that the kid will non be able to hold .. By keeping communicating channels with parents, and recommending for the kids within the wellness services that can happen their ambitious behaviors hard to pull off ( a barrier to wellbeing ) , the well-being of both the kid and parent/s is promoted through family-centred attention. In unit 7 ( K346, Block 2, Unit 7 ) we looked at resiliency theory based on doing good despite inauspicious fortunes , which focuses on kids s strengths instead than exposures ( K346, Block 2, Unit 7, p.91 ) . Though the parents of my mark group do by and large hold high outlooks for them, the immature people s exposures are overpowering and bound development of resiliency. They have no penetration into how their behavior impacts on others, or if others behaviour is harmful to them. They have no job work outing or life- accomplishments and need motivating from a cardinal grownup at all clip to run into their basic day-to-day life demands. The accent is more around maintaining safe ; but in making so we are restricting their experiences based on their behavior presentation and unwittingly non advancing resiliency. For the parents resiliency is promoted. As this group pass the school-holidays at place the bulk of parents have support from paid carers which provides consistence and supports the parent s well-being. This provides modus operandi for the immature people so advancing their well-being. We can mensurate whether their degree of well-being is maintained through vacation periods by whether parents have to entree the exigency contact for support due to escalation in behavior, or return early to school on an exigency respite footing. To avoid this parents are encouraged to take portion in developing behaviour support programs which can go on over the vacation periods. Returning to Bradshaw and Mayhew ( 2005 ) wellbeing groups how is wellbeing promoted or challenged within my mark group? Physical well-being: in activity 6.11 we looked at the wellness of kids in attention ( K346, Block 2, Unit 6, Activity 6.11 ) . The article by Rodrigues ( 2003 ) indicated that kids in attention have higher physical and mental wellness demands and that local attention services do non run into these demands. Unmet needs encompassed alveolar consonant, GP, and optician. Through service degree understandings we guarantee wellness appraisals are completed six-monthly, our GP visits hebdomadally to help building-up a curative relationship with the immature people helping wellness monitoring and signposting to secondary attention services. Our tooth doctor is a specific larning disablements dentist pro-active in run intoing unwritten wellness demands. An optician visits yearly and is adept at function drama and accommodating trials to single tolerance degrees. I therefore feel we do non hold any unmet wellness demands in a group in attention with complex demands. Due to a profuseness of hazard appraisals and a civilization of continual dynamic hazard appraisals accidents are minor ; hurts tend to happen in staff due to aggressive behaviors. Diets are individualised and height and weight are closely monitored. Due to the stable and monitored environment the immature people are in, disregard and maltreatment is non in grounds. This may be more of a hazard during school vacations when parents have the force per unit areas of caring for the immature individual. Cognitive well-being: through being placed with us cognitive wellbeing has been identified as a concern and documented within statements of educational demands. Through statutory reappraisals this is monitored and governments are happy that they attend school daily. The educational attainment of my mark group is improbable to of all time be that above a three twelvemonth old. Through the Education Act 1996 ( www.legislation.gov.uk ) for those aged 5-16 instruction is mandatory. Due to the low degree of operation of this group it is difficult to show how their cognitive well-being is being addressed via schoolroom activities. The school does integrate a life-skills attack concentrating on bettering self-care accomplishments which will be more good to them in maturity, therefore bettering long-run well-being. Behavioral well-being: within my group entree to drugs, intoxicant and baccy is limited. The immature people are neer entirely within the residential environment or in the community. Their behaviour presentation when dying and therefore disputing creates barriers to overall well-being and may take onto the demand for drug therapy ; when inauspicious side-effects develops this so impacts on well-being. Emotional well-being: in Activity 5.6 ( K346, Block 2, Unit 5 ) we looked at what is of import in stripling s quality of life ; relationships with equals was found to be really of import. Due to my groups really hapless societal accomplishments their relationships tend to be merely with the grownups caring for them. I can happen no research that demonstrates deficiency of equal support for this group is damaging to them, possibly as they lack the penetration to seek it out in the first topographic point. In activity 10.3 ( K346, Block 2, Unit 10 ) we examined psychological emphasis and anxiousness in immature people and how this impacts on wellbeing. Inability to develop accomplishments in deciding jobs and stressors was found to be damaging. My group live in a ageless anxiousness province and can non get by with the slightest alteration. Their emotional well-being is continually undermined through their status. By supplying an environment that is unagitated and familiar and fixing them for alteration we try to equilibrate this facet of well-being, though it is a changeless challenge. In activity 10.6 the nature of kid and adolescent mental wellness jobs ( K346, Block 2, Unit 10 ) the article discussed that those with terrible larning disablements have a high incidence of mental wellness jobs every bit good as their upset. We monitor mental wellness through our service degree understanding with CAMHS. The complex demands of this group mean they receive regular reappraisals. In decision the significance of wellbeing in this group is difficult to specify due to their associated jobs through their diagnosing. Though their well-being is promoted through robust wellness monitoring and run intoing their daily life demands, we can non supply any longer than that as they can non pass on their demands more to the full. They are to the full safeguarded to such an extent that their every move is monitored ; and for this group of immature people I feel this is necessary as to make any other would direct them gyrating as they are unable to get by with the normal challenges of mundane life, and that in itself would be barbarous.

Renaissance Essay Example | Topics and Well Written Essays - 500 words

Renaissance - Essay Example All these paintings are extremely soothing as they, "appeal to both the mind and spirit" (Portrait of the Artist). These paintings reflect the artist's unique and personal style. The painting that I have chosen, 'Madonna and Child with Adoring Angel' (Tempera on panel, Norton Simon Art Foundation), is exceptional for its three dimensional effect as obtained by the view of the country-side in the background as seen through the window arches. Equally brilliant is how the artist has captured the expressions of love, tenderness and adoration on the faces of his three subjects. The attention paid to the surroundings in the form of the pillars and arches also lend authenticity to the entire composition. All these aspects combined give depth and perspective to the painting as well as a sense of realism, which was a hallmark of art of this period. The artist has gone in to minute detail in every aspect of the painting - be it the main subjects, the overall setting and even the decorative aspects. For example, the depiction of the decorations on the panels and arches makes one fell as if one were actually present in the room.